Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 27th March 2019 from 11:00 AM to 1:00 PM (GMT).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 34, 2018
Previous Article Next Article

Iodine-mediated cross-dehydrogenative coupling of pyrazolones and alkenes

Author affiliations

Abstract

An iodine-mediated alkenylation of pyrazolones with simple alkenes under an air atmosphere has been developed. By this protocol, the pharmaceutically relevant pyrazolone scaffold was directly adorned with a readily transformable olefinic functional group through a cross-dehydrogenative coupling process in moderate to excellent yields. The coupling products could be facilely manipulated by, for example, the Heck reaction and hydrogenation treatment, thus enriching the pyrazolone derivatives. Based on the observation of the reaction intermediate and mechanistical experiments, two possible reaction pathways were proposed.

Graphical abstract: Iodine-mediated cross-dehydrogenative coupling of pyrazolones and alkenes

Back to tab navigation

Supplementary files

Publication details

The article was received on 12 Jul 2018, accepted on 07 Aug 2018 and first published on 09 Aug 2018


Article type: Paper
DOI: 10.1039/C8OB01645C
Citation: Org. Biomol. Chem., 2018,16, 6275-6283

  •   Request permissions

    Iodine-mediated cross-dehydrogenative coupling of pyrazolones and alkenes

    K. Yang, X. Bao, Y. Yao, J. Qu and B. Wang, Org. Biomol. Chem., 2018, 16, 6275
    DOI: 10.1039/C8OB01645C

Search articles by author

Spotlight

Advertisements