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A fast-response and highly specific Si-Rhodamine probe for endogenous peroxynitrite detection in living cells

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Abstract

Peroxynitrite (ONOO) is involved in a variety of physiological and pathological processes. We designed and synthesized a fluorescent probe SiNH based on Si-rhodamine. The nanoprobe SiNH encapsulated within the amphiphilic copolymer exhibited fast response within 10 s, and it was highly specific for ONOO in aqueous solution. It is demonstrated that the nanoprobe SiNH is applicable for real-time tracing of endogenous ONOO in living cells.

Graphical abstract: A fast-response and highly specific Si-Rhodamine probe for endogenous peroxynitrite detection in living cells

  • This article is part of the themed collection: New Talent
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Publication details

The article was received on 06 Jul 2018, accepted on 30 Jul 2018 and first published on 30 Jul 2018


Article type: Paper
DOI: 10.1039/C8OB01598H
Citation: Org. Biomol. Chem., 2018, Advance Article
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    A fast-response and highly specific Si-Rhodamine probe for endogenous peroxynitrite detection in living cells

    J. Tang, Q. Li, Z. Guo and W. Zhu, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C8OB01598H

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