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Issue 36, 2018
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Cu-Catalyzed/mediated synthesis of N-fluoroalkylanilines from arylboronic acids: fluorine effect on the reactivity of fluoroalkylamines

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Abstract

An oxidative coupling reaction of fluoroalkylamines with arylboronic acids has been achieved for the first time. Fluorine has profound influence on the reactivity and fluoroalkylated amines have the following reactivity trend: difluoroethylamine > trifluoroethylamine > pentafluoropropylamine ≈ heptafluorobutylamine.

Graphical abstract: Cu-Catalyzed/mediated synthesis of N-fluoroalkylanilines from arylboronic acids: fluorine effect on the reactivity of fluoroalkylamines

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Publication details

The article was received on 05 Jul 2018, accepted on 03 Aug 2018 and first published on 03 Aug 2018


Article type: Communication
DOI: 10.1039/C8OB01581C
Citation: Org. Biomol. Chem., 2018,16, 6634-6637
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    Cu-Catalyzed/mediated synthesis of N-fluoroalkylanilines from arylboronic acids: fluorine effect on the reactivity of fluoroalkylamines

    H. Wang, Y. Tu, D. Liu and X. Hu, Org. Biomol. Chem., 2018, 16, 6634
    DOI: 10.1039/C8OB01581C

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