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Cobalt(II)-catalyzed regioselective C–H halogenation of anilides

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Abstract

A cobalt-catalyzed regioselective C–H halogenation methodology is reported herein. The highlight of this work is the highly selective C–H functionalization of anilides, which results in high-yielding, versatile, and practical halogenated products. Thereby, brominations, chlorinations and iodinations of many electron-rich and electron-deficient anilides were achieved in a highly selective fashion. Mechanistic studies with respect to the pathway of the reaction are also described.

Graphical abstract: Cobalt(ii)-catalyzed regioselective C–H halogenation of anilides

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Publication details

The article was received on 20 Jun 2018, accepted on 10 Jul 2018 and first published on 10 Jul 2018


Article type: Paper
DOI: 10.1039/C8OB01448E
Citation: Org. Biomol. Chem., 2018, Advance Article
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    Cobalt(II)-catalyzed regioselective C–H halogenation of anilides

    Z. Li, K. Sun and C. Cai, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C8OB01448E

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