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Issue 30, 2018
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Cobalt(ii)-catalyzed regioselective C–H halogenation of anilides

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A cobalt-catalyzed regioselective C–H halogenation methodology is reported herein. The highlight of this work is the highly selective C–H functionalization of anilides, which results in high-yielding, versatile, and practical halogenated products. Thereby, brominations, chlorinations and iodinations of many electron-rich and electron-deficient anilides were achieved in a highly selective fashion. Mechanistic studies with respect to the pathway of the reaction are also described.

Graphical abstract: Cobalt(ii)-catalyzed regioselective C–H halogenation of anilides

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Supplementary files

Article information

20 Jun 2018
10 Jul 2018
First published
10 Jul 2018

Org. Biomol. Chem., 2018,16, 5433-5440
Article type

Cobalt(II)-catalyzed regioselective C–H halogenation of anilides

Z. Li, K. Sun and C. Cai, Org. Biomol. Chem., 2018, 16, 5433
DOI: 10.1039/C8OB01448E

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