Qin Yang, Minhao Lou, Zhijian Yin, Zhihong Deng, Qiuping Ding and Yiyuan Peng
Org. Biomol. Chem., 2018,16, 8724-8731
DOI:
10.1039/C8OB01429A,
Paper
A novel and efficient protocol for the direct C-4 alkylation of quinazoline-3-oxides via radical oxidative coupling between quinazoline 3-oxides and ethers in the presence of TBHP was developed. The reaction proceeded smoothly under metal-free conditions, which provided quinazoline-containing heterocyclic molecules in moderate to good yields.
