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Issue 30, 2018
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An organocatalytic asymmetric Mannich reaction for the synthesis of 3,3-disubstituted-3,4-dihydro-2-quinolones

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Abstract

The first organocatalytic asymmetric Mannich reaction employing 3,4-dihydro-2-quinolones has been developed for the synthesis of biologically important 3,3-disubstituted-dihydro-2-quinolones. N-Boc imine precursor amidosulfones as well as pre-formed N-Boc imine were used for this purpose. Cyclohexyldiamine derived bifunctional amino-thiourea catalysts were employed to provide the products in high enantio- and good diastereoselectivities.

Graphical abstract: An organocatalytic asymmetric Mannich reaction for the synthesis of 3,3-disubstituted-3,4-dihydro-2-quinolones

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Publication details

The article was received on 13 Jun 2018, accepted on 11 Jul 2018 and first published on 11 Jul 2018


Article type: Communication
DOI: 10.1039/C8OB01399C
Citation: Org. Biomol. Chem., 2018,16, 5407-5411
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    An organocatalytic asymmetric Mannich reaction for the synthesis of 3,3-disubstituted-3,4-dihydro-2-quinolones

    S. Mukhopadhyay and S. C. Pan, Org. Biomol. Chem., 2018, 16, 5407
    DOI: 10.1039/C8OB01399C

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