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Issue 33, 2018
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Copper-catalyzed generation of flavone selenide and thioether derivatives using KSeCN and KSCN via C–H functionalization

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Abstract

Flavone selenide or sulfur-containing derivatives are pretty valuable in drug discovery due to their diversity of important bioactivities. Here, two simple Cu-catalyzed methods of constructing C–Se and C–S bonds on flavone skeletal structures via C–H functionalization are reported, which regioselectively afford flavone selenide and sulfide derivatives in good yields using cheap KSeCN or KSCN salts as selenium and sulfur agents. These methods further enrich the current C–Se and C–S bond construction methods.

Graphical abstract: Copper-catalyzed generation of flavone selenide and thioether derivatives using KSeCN and KSCN via C–H functionalization

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Publication details

The article was received on 13 Jun 2018, accepted on 22 Jul 2018 and first published on 25 Jul 2018


Article type: Paper
DOI: 10.1039/C8OB01398E
Citation: Org. Biomol. Chem., 2018,16, 5999-6005
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    Copper-catalyzed generation of flavone selenide and thioether derivatives using KSeCN and KSCN via C–H functionalization

    J. Zhu, B. Xu, J. Yu, Y. Ren, J. Wang, P. Xie, C. U. Pittman and A. Zhou, Org. Biomol. Chem., 2018, 16, 5999
    DOI: 10.1039/C8OB01398E

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