Direct C–OH/P(O)–H dehydration coupling forming phosphine oxides†
A t-BuONa-mediated C–OH/P(O)–H cross dehydration coupling to produce alkylphosphine oxides is developed. This reaction employed readily available alcohols and P(O)–H compounds as the starting materials, providing an efficient alternative method for constructing sp3 C–P bonds. A reasonable reaction path involving dehydration and subsequent regio-selective hydrophosphorylation of the resulting alkenes was proposed.
- This article is part of the themed collection: Synthetic methodology in OBC