Issue 31, 2018

Pd(ii)-Catalyzed aerobic 1,2-difunctionalization of conjugated dienes: efficient synthesis of morpholines and 2-morpholones

Abstract

A novel and efficient methodology concerning the Pd(II)-catalyzed intermolecular difunctionalization of conjugated dienes is reported to synthesize a series of functionalized morpholines and 2-morpholones. Widely distributed and easily obtained β-amino alcohols and α-amino acids, as starting nitrogen and oxygen sources, are successfully applied in the difunctionalization of conjugated dienes respectively. The majority of the desired products were obtained in moderate to excellent yields. Oxygen was successfully employed as a terminal oxidant. Further transformation of the generated products allowed for the expansion of structural diversity.

Graphical abstract: Pd(ii)-Catalyzed aerobic 1,2-difunctionalization of conjugated dienes: efficient synthesis of morpholines and 2-morpholones

Supplementary files

Article information

Article type
Paper
Submitted
31 May 2018
Accepted
12 Jul 2018
First published
12 Jul 2018

Org. Biomol. Chem., 2018,16, 5618-5625

Pd(II)-Catalyzed aerobic 1,2-difunctionalization of conjugated dienes: efficient synthesis of morpholines and 2-morpholones

K. Wen, Z. Wu, B. Chen, J. Chen and W. Zhang, Org. Biomol. Chem., 2018, 16, 5618 DOI: 10.1039/C8OB01291A

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