Yuanyuan Wei, Jie Wang, Yajun Wang, Xiaoqiang Yao, Caixia Yang and Congde Huo
Org. Biomol. Chem., 2018,16, 4985-4989
DOI:
10.1039/C8OB01068D,
Paper
An auto-oxidation promoted sp3 C–H arylation reaction between N-aryl glycine derivatives and electron-rich arenes, leading to the formation of N-aryl α-aryl α-amino acid derivatives, is described. This atom-economical and environmentally benign reaction proceeds smoothly under mild reaction conditions and requires only Brønsted acid and oxygen (balloon). A plausible radical involved mechanism is proposed.
