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Issue 33, 2018
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Catalytic alkylation reactions of weakly acidic carbonyl and related compounds using alkenes as electrophiles

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Abstract

Catalytic alkylation reactions of weakly acidic carbonyl and related pronucleophiles such as amides, esters, and sulfonamides with substituted alkenes have been reported. In the presence of a strong Brønsted base catalyst system, potassium hexamethyldisilazide and 18-crown-6 ether, the desired reactions proceeded in high yields at ambient temperature with a wide substrate scope. These are atom-economical catalytic alkylation reactions of carbonyl and related compounds.

Graphical abstract: Catalytic alkylation reactions of weakly acidic carbonyl and related compounds using alkenes as electrophiles

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Publication details

The article was received on 21 Apr 2018, accepted on 08 Jun 2018 and first published on 08 Jun 2018


Article type: Paper
DOI: 10.1039/C8OB00941D
Citation: Org. Biomol. Chem., 2018,16, 5969-5972
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    Catalytic alkylation reactions of weakly acidic carbonyl and related compounds using alkenes as electrophiles

    Y. Yamashita, R. Igarashi, H. Suzuki and S. Kobayashi, Org. Biomol. Chem., 2018, 16, 5969
    DOI: 10.1039/C8OB00941D

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