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Issue 26, 2018
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Stabilization of an intermolecular i-motif by lipid modification of cytosine-oligodeoxynucleotides

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Abstract

This paper describes the stabilization of an intermolecular i-motif by lipophilic modification on the 3′-terminus of oligonucleotides. The hydrophobic aliphatic chain connected at the 3′-terminus of a trinucleotide (dC)3 promoted the formation of an i-motif and significantly enhanced the quadruplex's stability. The impact of lipophilic modification on i-motif's thermal stability was studied by UV-thermal denaturation melting experiments and isothermal titration calorimetry. We found that alkyl chains containing more than 14 carbon atoms could elevate the i-motif structure's stability in a wide range of pH and concentrations.

Graphical abstract: Stabilization of an intermolecular i-motif by lipid modification of cytosine-oligodeoxynucleotides

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Publication details

The article was received on 19 Apr 2018, accepted on 13 Jun 2018 and first published on 14 Jun 2018


Article type: Paper
DOI: 10.1039/C8OB00920A
Citation: Org. Biomol. Chem., 2018,16, 4857-4863
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    Stabilization of an intermolecular i-motif by lipid modification of cytosine-oligodeoxynucleotides

    Y. Sun, Y. Ji, D. Wang, J. Wang and D. Liu, Org. Biomol. Chem., 2018, 16, 4857
    DOI: 10.1039/C8OB00920A

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