Jérémie Tessier, Mahmood Golmohamadi, Kevin J. Wilkinson and Andreea R. Schmitzer
Org. Biomol. Chem., 2018,16, 4288-4294
DOI:
10.1039/C8OB00897C,
Paper
We designed and synthesized miconazole analogues containing a substituted imidazolium moiety. The structural modification of the miconazole led to a compound with high potency to prevent the formation and disrupt bacterial biofilms, as a result of accumulation in the biofilm matrix, permeabilization of the bacterial membrane and generation of reactive oxygen species in the cytoplasm.
