Issue 21, 2018

Copper-catalyzed remote oxidation of alcohols initiated by radical difluoroalkylation of alkenes: facile access to difluoroalkylated carbonyl compounds

Abstract

A Cu-catalyzed oxidation of alcohols triggered by the radical difluoroalkylation of alkenes has been developed, providing facile access to a series of difluoroalkylated ketones or aldehydes in moderate to high yields. The concurrent realization of the catalytic oxidation of alcohols and difluoroalkylation of alkenes enables a highly efficient and attractive method for organic synthesis.

Graphical abstract: Copper-catalyzed remote oxidation of alcohols initiated by radical difluoroalkylation of alkenes: facile access to difluoroalkylated carbonyl compounds

Supplementary files

Article information

Article type
Communication
Submitted
16 Apr 2018
Accepted
02 May 2018
First published
03 May 2018

Org. Biomol. Chem., 2018,16, 3876-3880

Copper-catalyzed remote oxidation of alcohols initiated by radical difluoroalkylation of alkenes: facile access to difluoroalkylated carbonyl compounds

J. Zhang, W. Jin, C. Cheng and F. Luo, Org. Biomol. Chem., 2018, 16, 3876 DOI: 10.1039/C8OB00889B

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