Jump to main content
Jump to site search

Issue 16, 2018
Previous Article Next Article

Cyrene as a bio-based solvent for HATU mediated amide coupling

Author affiliations

Abstract

Amide bonds are one of the underpinning linkages in all living systems and are fundamental within drug discovery. Current methods towards their synthesis frequently rely on the use of dipolar aprotic solvents; however, due to increasingly stringent regulations and growing societal pressures, safe and more sustainable alternatives are highly sought after. Herein, we evaluate the application of the bio-based solvent Cyrene™ in the HATU mediated synthesis of amides and peptides. We found that Cyrene functioned as a competent replacement for DMF in the synthesis of a series of lead-like compounds and dipeptides (25 examples, 63–100%).

Graphical abstract: Cyrene as a bio-based solvent for HATU mediated amide coupling

Back to tab navigation

Supplementary files

Article information


Submitted
16 Mar 2018
Accepted
27 Mar 2018
First published
03 Apr 2018

Org. Biomol. Chem., 2018,16, 2851-2854
Article type
Communication

Cyrene as a bio-based solvent for HATU mediated amide coupling

K. L. Wilson, J. Murray, C. Jamieson and A. J. B. Watson, Org. Biomol. Chem., 2018, 16, 2851
DOI: 10.1039/C8OB00653A

Social activity

Search articles by author

Spotlight

Advertisements