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Issue 16, 2018
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Binding-promoted chemical reaction in the nanospace of a binding site: effects of environmental constriction

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Abstract

Chemical reactions in a confined nanospace can be very different from those in solution. Imine formation between molecular amines and an aldehyde inside a molecularly imprinted receptor was promoted strongly by the binding. Although how well the amine fit in the binding pocket and its electronic nature both influenced the reaction, the freedom of movement for the amine was the most important factor determining the binding-normalized reactivity.

Graphical abstract: Binding-promoted chemical reaction in the nanospace of a binding site: effects of environmental constriction

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Supplementary files

Article information


Submitted
08 Mar 2018
Accepted
02 Apr 2018
First published
03 Apr 2018

Org. Biomol. Chem., 2018,16, 2855-2859
Article type
Communication
Author version available

Binding-promoted chemical reaction in the nanospace of a binding site: effects of environmental constriction

X. Xing and Y. Zhao, Org. Biomol. Chem., 2018, 16, 2855
DOI: 10.1039/C8OB00590G

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