A metal-free α-alkylation of alcohols with para-quinone methides (p-QMs) for accessing alcohol-containing phenols and dihydroisocoumarins has been developed. The alcohols were converted to α-oxy radicals in the presence of di-tert-butyl peroxide (DTBP), which were added to p-QMs for aromatization and C(sp3)–C(sp3) bond formation.
The article was received on 07 Mar 2018, accepted on 14 Mar 2018 and first published on 16 Mar 2018
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