Jifeng Qi, Ziyang Deng, Bo Huang and Sunliang Cui
Org. Biomol. Chem., 2018,16, 2762-2767
DOI:
10.1039/C8OB00568K,
Paper
A metal-free α-alkylation of alcohols with para-quinone methides (p-QMs) for accessing alcohol-containing phenols and dihydroisocoumarins has been developed. The alcohols were converted to α-oxy radicals in the presence of di-tert-butyl peroxide (DTBP), which were added to p-QMs for aromatization and C(sp3)–C(sp3) bond formation.