Jump to main content
Jump to site search

Issue 16, 2018
Previous Article Next Article

Ene cyclization reaction in heterocycle synthesis

Author affiliations

Abstract

The ene cyclization has evolved to become an indispensable tool for the synthesis of various ring size heterocyclic compounds. In the past and recent years, many exciting reports have demonstrated the broad scope and synthetic utility of ene cyclization and the versatility of oxonium ion, iminium ion and thionium ion intermediates. Moreover, the ease of regio- and stereoselectivity of ene cyclization has led to the development of new types of heterocyclic compounds. This article aims at reviewing the utilities of ene cyclization reactions for the synthesis of various ring sizes of oxygen, nitrogen and sulfur heterocycles. It also covers some applications in natural product synthesis. The mechanism of the reactions is discussed wherever necessary. The review article covers the time period from 1986 to 2017.

Graphical abstract: Ene cyclization reaction in heterocycle synthesis

Back to tab navigation

Article information


Submitted
19 Feb 2018
Accepted
20 Mar 2018
First published
20 Mar 2018

Org. Biomol. Chem., 2018,16, 2820-2840
Article type
Review Article

Ene cyclization reaction in heterocycle synthesis

P. Saha and A. K. Saikia, Org. Biomol. Chem., 2018, 16, 2820
DOI: 10.1039/C8OB00429C

Social activity

Search articles by author

Spotlight

Advertisements