Jixing Li, Wenxia Cong, Zeng Gao, Jinlong Zhang, Huameng Yang and Gaoxi Jiang
Org. Biomol. Chem., 2018,16, 3479-3486
DOI:
10.1039/C8OB00318A,
Paper
A new approach for highly regioselective iodination of azobenzenes with alkyl iodide as the iodinating reagent enabled by Rh-catalyzed oxidative C–H activation has been developed. By changing the oxidant, various mono- and di-iodinated azobenzenes were smoothly obtained in moderate to excellent yields, respectively. The preliminary mechanistic study reveals that the reaction process might undergo electrophilic substitution of the directed ortho metalated five-membered rhodacycle compound by an iodine cationic species generated in situ from alkyl iodide and oxidant.