The first total synthesis of gobichelin B: a mixed-ligand siderophore of Streptomyces sp. NRRL F-4415

Perali Ramu Sridhar; B. C. Venkatesh; Shaik Kalesha; Chalapala Sudharani

doi:10.1039/C8OB00263K

The first total synthesis of gobichelin B: a mixed-ligand siderophore of Streptomyces sp. NRRL F-4415†

Perali Ramu Sridhar,

*^a B. C. Venkatesh,^a Shaik Kalesha^a and Chalapala Sudharani^a

Author affiliations

* Corresponding authors

^a School of Chemistry, University of Hyderabad, Gachibowli, Hyderabad – 500 046, India
E-mail: p_ramu_sridhar@uohyd.ac.in

Abstract

The first total synthesis of a structurally diverse mixed ligand siderophore, gobichelin B produced by Streptomyces sp. NRRL F-4415, is reported. The systematic assembly of the building blocks to synthesize Gob-B 1^st half and Gob-B 2^nd half and subsequent coupling of these two fragments followed by global deprotection using Pearlman's catalyst led to the isolation of gobichelin B in excellent yield and purity.

This article is part of the themed collection: Total synthesis in OBC

Supplementary files

Publication details

The article was received on 31 Jan 2018, accepted on 12 Mar 2018 and first published on 13 Mar 2018

Article type: Paper

DOI: 10.1039/C8OB00263K

Citation: Org. Biomol. Chem., 2018,16, 3732-3740

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The first total synthesis of gobichelin B: a mixed-ligand siderophore of Streptomyces sp. NRRL F-4415

P. R. Sridhar, B. C. Venkatesh, S. Kalesha and C. Sudharani, Org. Biomol. Chem., 2018, 16, 3732
DOI: 10.1039/C8OB00263K
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Organic & Biomolecular Chemistry

The first total synthesis of gobichelin B: a mixed-ligand siderophore of Streptomyces sp. NRRL F-4415†

Abstract

Supplementary files

Publication details

The first total synthesis of gobichelin B: a mixed-ligand siderophore of Streptomyces sp. NRRL F-4415

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