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Issue 7, 2018
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Electrophilic fluorination of stereodefined disubstituted silyl ketene hemiaminals en route to tertiary α-fluorinated carbonyl derivatives

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Abstract

A highly diastereoselective synthesis of tertiary α-fluoro carbonyl compounds is reported in only two chemical steps from a simple alkyne through the reaction of stereodefined fully substituted silyl ketene hemiaminal derivatives with Selectfluor.

Graphical abstract: Electrophilic fluorination of stereodefined disubstituted silyl ketene hemiaminals en route to tertiary α-fluorinated carbonyl derivatives

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Article information


Submitted
09 Jan 2018
Accepted
16 Jan 2018
First published
16 Jan 2018

Org. Biomol. Chem., 2018,16, 1079-1082
Article type
Communication

Electrophilic fluorination of stereodefined disubstituted silyl ketene hemiaminals en route to tertiary α-fluorinated carbonyl derivatives

J. Q. Huang, Z. Nairoukh and I. Marek, Org. Biomol. Chem., 2018, 16, 1079
DOI: 10.1039/C8OB00067K

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