Yingchao Zhang, Chunxia Wen and Jizhen Li
Org. Biomol. Chem., 2018,16, 1912-1920
DOI:
10.1039/C7OB03059B,
Paper
A novel and efficient regioselective C–H fluorination of 8-aminoquinoline amides and sulfonamides at the C5 position was achieved. Using Selectfluor as a “F” reagent and HOAc as an additive, the reaction proceeds smoothly via a radical pathway. This method features metal-free conditions, a broad substrate scope and operational simplicity.
