Jump to main content
Jump to site search

Issue 11, 2018
Previous Article Next Article

C5-Regioselective C–H fluorination of 8-aminoquinoline amides and sulfonamides with Selectfluor under metal-free conditions

Author affiliations

Abstract

A novel and efficient regioselective C–H fluorination of 8-aminoquinoline amides and sulfonamides at the C5 position was achieved. Using Selectfluor as a “F” reagent and HOAc as an additive, the reaction proceeds smoothly via a radical pathway. This method features metal-free conditions, a broad substrate scope and operational simplicity.

Graphical abstract: C5-Regioselective C–H fluorination of 8-aminoquinoline amides and sulfonamides with Selectfluor under metal-free conditions

Back to tab navigation

Supplementary files

Article information


Submitted
11 Dec 2017
Accepted
29 Jan 2018
First published
29 Jan 2018

Org. Biomol. Chem., 2018,16, 1912-1920
Article type
Paper

C5-Regioselective C–H fluorination of 8-aminoquinoline amides and sulfonamides with Selectfluor under metal-free conditions

Y. Zhang, C. Wen and J. Li, Org. Biomol. Chem., 2018, 16, 1912
DOI: 10.1039/C7OB03059B

Social activity

Search articles by author

Spotlight

Advertisements