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Issue 7, 2018
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Synthesis of a novel HER2 targeted aza-BODIPY–antibody conjugate: synthesis, photophysical characterisation and in vitro evaluation

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Abstract

We herein report the synthesis and analysis of a novel aza-BODIPY–antibody conjugate, formed by controlled and regioselective bioconjugation methodology. Employing the clinically relevant antibody, which targets HER2 positive cancers, represents an excellent example of an antibody targeting strategy for this class of near-IR emitting fluorophore. The NIR fluorescence and binding properties were validated through in vitro studies using live cell confocal imaging.

Graphical abstract: Synthesis of a novel HER2 targeted aza-BODIPY–antibody conjugate: synthesis, photophysical characterisation and in vitro evaluation

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Supplementary files

Article information


Submitted
30 Nov 2017
Accepted
16 Jan 2018
First published
16 Jan 2018

This article is Open Access

Org. Biomol. Chem., 2018,16, 1144-1149
Article type
Paper

Synthesis of a novel HER2 targeted aza-BODIPY–antibody conjugate: synthesis, photophysical characterisation and in vitro evaluation

Miffy. H. Y. Cheng, A. Maruani, H. Savoie, V. Chudasama and Ross. W. Boyle, Org. Biomol. Chem., 2018, 16, 1144
DOI: 10.1039/C7OB02957H

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