A mild method for synthesizing carboxylic acids by oxidation of aldoximes using hypervalent iodine reagents

Akira Nakamura; Hodaka Kanou; Junki Tanaka; Akira Imamiya; Tomohiro Maegawa; Yasuyoshi Miki

doi:10.1039/C7OB02858J

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A mild method for synthesizing carboxylic acids by oxidation of aldoximes using hypervalent iodine reagents†

Akira Nakamura,

^a Hodaka Kanou,^a Junki Tanaka,^a Akira Imamiya,^a Tomohiro Maegawa

*^a and Yasuyoshi Miki*^ab

Author affiliations

* Corresponding authors

^a School of Pharmaceutical Sciences, Kindai University, 3-4-1 Kowakae, Higashi-osaka, Osaka 577-8502, Japan
E-mail: maegawa@phar.kindai.ac.jp

^b Research Organization of Science and Technology, Research Center for Drug Discovery and pharmaceutical Science, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu, Shiga 525-8577, Japan

Abstract

A mild oxidation method for the conversion of aldoximes to carboxylic acids was developed mediated by hypervalent iodine reagents. This method covers a wide range of functionalized aldoximes and proceeds under mild conditions, utilizing PhI(OH)OTs as an oxidant.

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Supplementary files

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Article information

DOI: https://doi.org/10.1039/C7OB02858J
Article type: Communication
Submitted: 21 Nov 2017
Accepted: 02 Jan 2018
First published: 02 Jan 2018

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Org. Biomol. Chem., 2018,16, 541-544

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A mild method for synthesizing carboxylic acids by oxidation of aldoximes using hypervalent iodine reagents

A. Nakamura, H. Kanou, J. Tanaka, A. Imamiya, T. Maegawa and Y. Miki, Org. Biomol. Chem., 2018, 16, 541 DOI: 10.1039/C7OB02858J

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Organic & Biomolecular Chemistry

A mild method for synthesizing carboxylic acids by oxidation of aldoximes using hypervalent iodine reagents†

Abstract

Supplementary files

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A mild method for synthesizing carboxylic acids by oxidation of aldoximes using hypervalent iodine reagents

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