M. C. Bellucci, M. Frigerio, C. Castellano, F. Meneghetti, A. Sacchetti and A. Volonterio
Org. Biomol. Chem., 2018,16, 521-525
DOI:
10.1039/C7OB02680C,
Communication
A collection of systematically substituted 3-cyclo-butylcarbamoyl hydantoins was synthesized by a regioselective multicomponent domino process followed by easy coupling reactions. Calculations, NMR studies and X-ray analysis show that these scaffolds are able to project their side chains similar to common secondary structures, such as the α-helix and β-turn, with favourable enthalpic and entropic profiles.
