Issue 9, 2018

Synthesis of polyheterocycles via multicomponent reactions

Abstract

Polyheterocycles are one of the most desired synthetic targets due to their numerous and valuable applications in various fields. Multicomponent reactions (MCRs) are highly convergent one-pot processes, in which three or more reagents are combined sequentially to construct complex products, with almost all the atoms coming from the starting reagents. In this context, the syntheses of ‘heterocycles’ via MCR-based processes have been reviewed a number of times. However, there is not a single review (recent or otherwise) covering the synthesis of ‘polyheterocycles’ via a direct MCR or via a one-pot process involving MCRs coupled to further cyclizations (via ionic, metal-catalyzed, pericyclic, or free-radical-mediated cyclizations). This issue is consequently the main topic of the present review, which considers work from the last decade. The work is categorized according to the key processes involved in the syntheses of polyheterocycles, aiming to give readers an easy understanding of this MCR-based chemistry and to provide insights for further investigations. The reaction mechanisms providing novel elements to these MCR-based methods for the synthesis of polyheterocycles are also discussed.

Graphical abstract: Synthesis of polyheterocycles via multicomponent reactions

Article information

Article type
Review Article
Submitted
14 Sep 2017
Accepted
29 Nov 2017
First published
29 Nov 2017

Org. Biomol. Chem., 2018,16, 1402-1418

Synthesis of polyheterocycles via multicomponent reactions

I. A. Ibarra, A. Islas-Jácome and E. González-Zamora, Org. Biomol. Chem., 2018, 16, 1402 DOI: 10.1039/C7OB02305G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements