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Issue 2, 2019
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Neoadjuvant nano-photothermal therapy used before operation effectively assists in surgery for breast cancer

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Abstract

Nano-photothermal therapy (NPTT) has attracted increasing interest recently due to its high efficiency, excellent selectivity and non-ionizing radiation damage. Despite a tremendous amount of exciting pre-clinical results reported in the past few years, however, the further clinic application of NPTT is still difficult. To combine NPTT with clinical surgery more closely, novel multifunctional optical-magnetic nanosystems have been synthesized and applied for preoperative NPTT to assist in the follow-up surgery, termed “neoadjuvant NPTT”. Remarkably, nanoparticles are mainly aggregated in the cytoplasm of tumor cells in vitro and largely accumulated in the tumor in vivo 24 h after injection. Under the guidance of tri-modality imaging, preoperative NPTT could shrink the tumor in a short time and make the boundary between the tumor and surrounding normal tissues clearer, which is conducive to subsequent surgery resection. Furthermore, the 50% survival rate is up to 50 days compared with 35 days for standard surgery, 31 days for PTT alone and 24 days for non-surgery groups. Therefore, NPTT can effectively assist in surgery used before operation. This study provides a new idea for the clinical transformation of NPTT in the future.

Graphical abstract: Neoadjuvant nano-photothermal therapy used before operation effectively assists in surgery for breast cancer

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Publication details

The article was received on 07 Oct 2018, accepted on 27 Nov 2018 and first published on 30 Nov 2018


Article type: Paper
DOI: 10.1039/C8NR08109C
Nanoscale, 2019,11, 706-716

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    Neoadjuvant nano-photothermal therapy used before operation effectively assists in surgery for breast cancer

    H. Yan, W. Shang, X. Sun, L. Zhao, X. Wang, S. Zhang, N. Xu, W. Xu, J. Tian and F. Kang, Nanoscale, 2019, 11, 706
    DOI: 10.1039/C8NR08109C

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