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Neoadjuvant Nano-photothermal Therapy Used Before Operation Effectively Assists Surgery for Breast Cancer

Abstract

ABSTRACT: Nano-photothermal therapy (NPTT) has attracted increasing interests recently due to its high efficiency, excellent selectivity and non-ionizing radiation damage. Despite a tremendous amount of exciting pre-clinical results reported in the past few years, however, the further clinic application of NPTT is still difficult. To combine NPTT with clinical surgery more closely, novel multifunctional optical-magnetic nanosystems are synthesized and applied for preoperative NPTT to assist the follow-up surgery, termed as “Neoadjuvant NPTT”. Remarkably, the nanoparticles are mainly aggregated in the cytoplasm of tumor cells in vitro and largely accumulated in the tumor in vivo 24 h after injection. Under the guidance of tri-modality imaging, preoperative NPTT could shrink the tumor in a short time and make the boundary between tumor and surrounding normal tissues clearer, which is conducive to subsequent surgery resection. Furthermore, the 50% survival rate is up to 50 days compared with 35 days for standard surgery, 31 days for PTT alone and 24 days for non-surgery group. Therefore, NPTT can effectively assist surgery used before operation. This study provides a new idea for the clinical transformation of NPTT in future.

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Publication details

The article was received on 07 Oct 2018, accepted on 27 Nov 2018 and first published on 30 Nov 2018


Article type: Paper
DOI: 10.1039/C8NR08109C
Citation: Nanoscale, 2018, Accepted Manuscript
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    Neoadjuvant Nano-photothermal Therapy Used Before Operation Effectively Assists Surgery for Breast Cancer

    H. Yan, W. Shang, X. Sun, L. zhao, X. Wang, S. Zhang, N. Xu, W. H. Xu, J. Tian and F. Kang, Nanoscale, 2018, Accepted Manuscript , DOI: 10.1039/C8NR08109C

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