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Folate Receptor-Targeted Theranostic IrSx Nanoparticles for Multimodal Imaging-Guided Combined Chemo-Photothermal Therapy

Abstract

Nano-drug delivery system with multi-modality imaging capacities is worth pursuing because it integrates diagnostic and therapeutic functions. Herein, we report the design, synthesis and evaluation of modified iridium sulfide (IrSx) nanoparticles (NPs) for cancer therapy in vitro and in vivo. This nanosystem has been prepared by modifying IrSx with polyethylene glycol (PEG) conjugated to the targeting ligand folate (FA) for multimodal imaging-guided combined chemo-photothermal therapy. Upon PEG modification, the small IrSx NPs (about 4 nm) self-assemble into much larger (about 120 nm) IrSx-PEG-FA NPs that possess high photostability, ideal photothermal effect, high drug loading and pH-/photothermal-responsive drug release properties. By using a model anticancer drug, camptothecin (CPT), we demonstrate that CPT@IrSx-PEG-FA can effectively target FA-receptor-positive cancer cells in vitro and show efficient tumor accumulation in vivo. The combination of CPT@IrSx-PEG-FA treatment and irradiation with an 808 nm laser results in complete tumor elimination. Moreover, photothermal/photoacoustic (PA)/computed tomography (CT) imaging provides effective means to monitor the therapeutic effects. Interestingly, the nanoparticles can be cleared resulting in low systematic toxicity of CPT@IrSx-PEG-FA. Our work demonstrates that these prepared IrSx-PEG-FA NPs present a promising platform for the construction of multifunctional theranostic agents for cancer therapy.

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Publication details

The article was received on 06 Oct 2018, accepted on 31 Oct 2018 and first published on 02 Nov 2018


Article type: Paper
DOI: 10.1039/C8NR08095J
Citation: Nanoscale, 2018, Accepted Manuscript
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    Folate Receptor-Targeted Theranostic IrSx Nanoparticles for Multimodal Imaging-Guided Combined Chemo-Photothermal Therapy

    D. Zhang, Y. Zheng, H. zhang, G. Yang, C. Tan, L. He, L. Ji and Z. Mao, Nanoscale, 2018, Accepted Manuscript , DOI: 10.1039/C8NR08095J

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