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Integrating in situ formation of nanozyme with three-dimensional dendritic mesoporous silica nanospheres for hypoxia-overcoming photodynamic therapy

Abstract

Despite great progress in photodynamic therapy (PDT), the therapeutic effect is still limited by some points, such as tumor hypoxia, the short lifetime and limited action region of 1O2. Herein, a special kind of three-dimensional dendritic mesoporous silica nanospheres (3D-dendritic MSNs) are synthesized and used as robust nanocarriers to deliver abundant hydrophobic photosensitizers chlorin e6 (Ce6) to the A549 lung cancer cells. To address the tumor hypoxia, the nanozyme Pt nanoparticles (Pt NPs) are immobilized onto the channels of 3D-dendritic MSNs to catalyze the intracellular H2O2 producing plenty of oxygen. Moreover, due to the in situ reduction process, the uniform Pt NPs distribute well on the surface of 3D-dendritic MSNs with homogeneous high dispersity. Additionally, a mitochondria-targeting ligand triphenylphosphine (TPP) is conjugated to the Pt-decorated 3D-dendritic MSN composites to form a mitochondrial targeted system for the PDT of A549 cell. In a combination of the peroxidase-like Pt NPs and TPP with mitochondria-targeting ability, reactive oxygen species (ROS) burst in the mitochondria is achieved and subsequently results in the cell apoptosis. This sophisticated system shows an enhanced PDT effect of killing A549 cells, and promotes a new H2O2-activatable strategy to overcome hypoxia for tumor PDT.

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Publication details

The article was received on 20 Sep 2018, accepted on 05 Nov 2018 and first published on 05 Nov 2018


Article type: Paper
DOI: 10.1039/C8NR07679K
Citation: Nanoscale, 2018, Accepted Manuscript
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    Integrating in situ formation of nanozyme with three-dimensional dendritic mesoporous silica nanospheres for hypoxia-overcoming photodynamic therapy

    X. cai, Y. Luo, Y. Song, D. Liu, H. Yan, H. Li, D. Du, C. Zhu and Y. Lin, Nanoscale, 2018, Accepted Manuscript , DOI: 10.1039/C8NR07679K

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