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[99mTc-HYNIC-N-dodecylamide]: A New Hydrophobic Tracer for Labelling reconstituted High-Density Lipoproteins (rHDL) for Radioimaging

Abstract

Despite the widespread use of nanotechnology in radio-imaging applications, lipoprotein based delivery systems received only limited attention so far. These studies involve the synthesis of a novel hydrophobic radio-imaging tracer consisting of a hydrazinonicotinic acid (HYNIC)-N-dodecylamide and 99mTc conjugate that can be encapsulated into rHDL nanoparticles (NPs). These rHDL NPs can selectively target the Scavenger Receptor type B1 (SR-B1) that is overexpressed on most cancer cells due to excess demand for cholesterol for membrane biogenesis and thus can target tumors in-vivo. We provide details of the tracer synthesis, characterization of rHDL/tracer complex, in-vitro uptake, stability studies and in-vivo application of this new radio-imaging approach.

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Publication details

The article was received on 13 Sep 2018, accepted on 16 Nov 2018 and first published on 21 Nov 2018


Article type: Paper
DOI: 10.1039/C8NR07484D
Citation: Nanoscale, 2018, Accepted Manuscript
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    [99mTc-HYNIC-N-dodecylamide]: A New Hydrophobic Tracer for Labelling reconstituted High-Density Lipoproteins (rHDL) for Radioimaging

    K. I. Olive, B. Ocampo-García, L. A. Lara, C. L. Santos Cuveas, N. J. Mancilla, M. A. Luna-Gutiérrez, L. Medina, B. Nagarajan, S. Raut, N. Sabnis, L. Prokai and A. Lacko, Nanoscale, 2018, Accepted Manuscript , DOI: 10.1039/C8NR07484D

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