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Continuous Processing of Phase-Change Materials into Uniform Nanoparticles for Near-Infrared-Triggered Drug Release

Abstract

We report a method based on interfacial, anti-solvent-induced precipitation in a fluidic device for the continuous and scalable processing of phase-change materials (PCMs) into uniform nanoparticles with controlled diameters in the range of 10–100 nm. A eutectic mixture of lauric acid and stearic acid, with a well-defined melting point at 39 oC, serves as an example to demonstrate the concept. In the fluidic device, a coaxial flow is created by introducing a PCM solution in ethanol and a lipid solution in water (the anti-solvent), as the focused and focusing phases, respectively. The formation of lipid-capped PCM nanoparticles is governed by diffusion-controlled mixing of ethanol and water. During the production, both doxorubicin (DOX, an anticancer drug) and indocyanine green (ICG, a near-infrared dye) can be readily loaded into the PCM nanoparticles to give a smart drug release system. Upon irradiation by near-infrared light, the photothermal heating caused by ICG can melt the PCM and thereby trigger the release of DOX. This work not only provides a new technique for the continuous processing of PCMs and other soft materials into uniform nanoparticles with controlled sizes but also demonstrates a biocompatible system for controlled release and related applications.

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Publication details

The article was received on 29 Aug 2018, accepted on 16 Oct 2018 and first published on 02 Nov 2018


Article type: Paper
DOI: 10.1039/C8NR07027J
Citation: Nanoscale, 2018, Accepted Manuscript
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    Continuous Processing of Phase-Change Materials into Uniform Nanoparticles for Near-Infrared-Triggered Drug Release

    Q. Chen, C. Zhu, D. Huo, J. Xue, H. Cheng, B. Guan and Y. Xia, Nanoscale, 2018, Accepted Manuscript , DOI: 10.1039/C8NR07027J

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