Jump to main content
Jump to site search

Issue 36, 2018
Previous Article Next Article

Mitochondria-targeting single-layered graphene quantum dots with dual recognition sites for ATP imaging in living cells

Author affiliations

Abstract

As a molecular unit of intracellular energy transfer, adenosine triphosphate (ATP) is significant for maintaining the energy balance in living cells and thus monitoring cellular ATP is important to assess cellular physiological functions. However, effective monitoring of cellular ATP still faces challenges owing to the similarity of ATP to other nucleoside polyphosphates. Herein, yellow emissive single-layered graphene quantum dots (s-GQDs) with dual recognition sites including π-conjugated single sheets and positively charged sites were developed. The s-GQDs exhibit a good mitochondria targeting ability and respond only to purine nucleotides and show good selectivity in discriminating tri-, di- and monophosphate nucleotides. The good selectivity should be attributed to the concurrent effect of π–π stacking and electrostatic interactions between filmy layered positive s-GQDs and negative purine nucleotides. Owing to the mitochondria targeting ability and dual recognition sites of the s-GQDs, the mitochondrial ATP fluctuation resulting from the activation and suppression of ATP in living cells has been successfully monitored.

Graphical abstract: Mitochondria-targeting single-layered graphene quantum dots with dual recognition sites for ATP imaging in living cells

Back to tab navigation

Supplementary files

Publication details

The article was received on 27 Jul 2018, accepted on 15 Aug 2018 and first published on 16 Aug 2018


Article type: Paper
DOI: 10.1039/C8NR06061D
Citation: Nanoscale, 2018,10, 17402-17408

  •   Request permissions

    Mitochondria-targeting single-layered graphene quantum dots with dual recognition sites for ATP imaging in living cells

    J. H. Liu, R. S. Li, B. Yuan, J. Wang, Y. F. Li and C. Z. Huang, Nanoscale, 2018, 10, 17402
    DOI: 10.1039/C8NR06061D

Search articles by author

Spotlight

Advertisements