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Urushiol-functionalized mesoporous silica nanoparticles and its self-assembly Janus membrane as a highly efficient hemostatic material

Abstract

Quick hemostasis plays a very important role in preventing hemorrhagic shock and death by controlling blood loss of the trauma in the civil and military accidents. An ideal quick hemostat should have tissue-adhesive functional groups, clotting factors activating components, and plasma non-permeable hydrophobic layer. Inspired by adhesive behavior of mussels, a novel efficient hemostat of urushiol-functionalized mesoporous silica nanoparticles (MSN@U) with core-shell structure was synthesized and its hemostatic performance was evaluated for the first time. MSN@U could form amphiphatic Janus membrane (a hydrophobic layer and a hydrophilic layer in one membrane) by interfacial self-assembly. The morphology and structure of MSN@U were characterized. The results showed that MSN@U possessed large specific surface area of 448.91 m2•g-1 and rich porous structure with average pore diameter of 3.94 nm. The hydrophilic catechol groups and the long hydrophobic alkyl groups of urushiol allowed MSN@U to self-assemble at the blood/air interface. The former made MSN@U tightly adhere onto blood vessel tissue through covalent bonds, while the latter formed a hydrophobic barrier layer which hindered blood from oozing. Meanwhile, MSN@U would accelerate clotting cascade reactions. These three effects made MSN@U to be a very quick hemostat with the hemostatic time of 22 ± 2 s on a rat liver laceration. Both in vitro and in vivo tests showed that it possessed better hemostatic effect and blood compatibility than MSN. Cell viability evaluations indicated that MSN@U had no cytotoxicity. MSN@U will be a safe and promising hemostatic agent for clinical application.

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Publication details

The article was received on 21 Jul 2018, accepted on 08 Nov 2018 and first published on 09 Nov 2018


Article type: Paper
DOI: 10.1039/C8NR05882B
Citation: Nanoscale, 2018, Accepted Manuscript
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    Urushiol-functionalized mesoporous silica nanoparticles and its self-assembly Janus membrane as a highly efficient hemostatic material

    J. Chen, W. Cheng, S. Chen, W. Xu, J. Lin, H. Liu and Q. Chen, Nanoscale, 2018, Accepted Manuscript , DOI: 10.1039/C8NR05882B

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