Jump to main content
Jump to site search

Issue 44, 2018
Previous Article Next Article

Bi2Se3 nanoplates for contrast-enhanced photoacoustic imaging at 1064 nm

Author affiliations


Photoacoustic (PA) imaging is a high-resolution biomedical imaging modality, which can be used to visualize biological tissues located beyond the limited penetration depth of existing optical imaging techniques. An optical wavelength of 1064 nm is of great interest in PA imaging due to low intrinsic absorption at this wavelength. Reduced absorption implies an increased depth of imaging, which enables several new clinical applications such as bladder imaging, gastrointestinal (GI) imaging, and sentinel lymph node (SLN) imaging. In addition, a 1064 nm Nd:YAG laser system enables a high power, cost-effective, and compact laser-based PA imaging system. However, at this wavelength, due to low intrinsic contrast, high absorption exogenous PA contrast agents are necessary for imaging. To this end, we present new Bi2Se3 nanoplates as PA contrast agents at 1064 nm wavelength for PA imaging. We successfully synthesized Bi2Se3 nanoplates and they exhibited relatively strong PA signals at 1064 nm. We confirmed the increased imaging depth of penetration by imaging the Bi2Se3-containing tube located 4.6 cm deep in biological tissues. We present in vivo PA imaging of the bladder, GI tract, and SLN in mice using a Bi2Se3 contrast agent establishing the clinical feasibility of these agents with a clinical photoacoustic/ultrasound imaging system. Our results confirm that Bi2Se3 nanoplates are promising PA contrast agents at 1064 nm that offer a high optical absorbance in the second NIR region providing a high contrast imaging and increased depth of penetration.

Graphical abstract: Bi2Se3 nanoplates for contrast-enhanced photoacoustic imaging at 1064 nm

Back to tab navigation

Supplementary files

Publication details

The article was received on 02 Jan 2018, accepted on 01 Sep 2018 and first published on 05 Sep 2018

Article type: Paper
DOI: 10.1039/C8NR05672B
Citation: Nanoscale, 2018,10, 20548-20558

  •   Request permissions

    Bi2Se3 nanoplates for contrast-enhanced photoacoustic imaging at 1064 nm

    S. Park, G. Park, J. Kim, W. Choi, U. Jeong and C. Kim, Nanoscale, 2018, 10, 20548
    DOI: 10.1039/C8NR05672B

Search articles by author