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Bi2Se3 Nanoplates for Contrast-enhanced Photoacoustic Imaging at 1064 nm

Abstract

Photoacoustic (PA) imaging is a high-resolution biomedical imaging modality, which can visualize biological tissues located beyond the limited penetration depth of existing optical imaging techniques. An optical wavelength of 1064 nm is of great interest in PA imaging due to low intrinsic absorption at this wavelength. Reduced absorption implies increased depth of imaging, which enables several new clinical applications such as bladder imaging, gastrointestinal (GI) imaging, and sentinel lymph node (SLN) imaging. In addition, an Nd:YAG laser system for 1064 nm enables a high power, cost-effective, and compact laser-based PA imaging system. However, at this wavelength, due to low intrinsic contrast, high absorption exogenous PA contrast agents are necessary for imaging. To this end, we present new Bi2Se3 nanoplates as a PA contrast agent at 1064 nm wavelength for PA imaging. We successfully synthesized Bi2Se3 nanoplates and they exhibited relatively strong PA signals at 1064 nm. We confirmed the increased imaging depth of penetration by imaging the Bi2Se3-containing tube located 4.6 cm deep in biological tissues. We present in vivo PA imaging of bladder, GI tract, and SLN in mice using Bi2Se3 contrast agent establishing the clinical feasibility of this agents with a clinical photoacoustic/ultrasound imaging system. Our results confirm that Bi2Se3 nanoplates is a promising PA contrast agent at 1064 nm that offers a high optical absorbance in the second NIR region providing a high contrast imaging and increased depth of penetration.

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Publication details

The article was received on 02 Jan 2018, accepted on 01 Sep 2018 and first published on 05 Sep 2018


Article type: Paper
DOI: 10.1039/C8NR05672B
Citation: Nanoscale, 2018, Accepted Manuscript
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    Bi2Se3 Nanoplates for Contrast-enhanced Photoacoustic Imaging at 1064 nm

    S. Park, G. Park, J. Kim, W. Choi, U. Jeong and C. Kim, Nanoscale, 2018, Accepted Manuscript , DOI: 10.1039/C8NR05672B

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