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Multicolor Nanobubbles for FRET/Ultrasound Dual-modal Contrast Imaging


The aim of this paper is to develop a novel fluorescence/ultrasound dual-modal contrast agent. We prepared multicolor nanobubbles through doping three fluorescence dyes for combined fluorescence and contrast enhanced ultrasound imaging. The nanobubbles based on fluorescence resonance energy transfer (FRET) with different doping dye ratio combinations exhibited multiple colors under one single wavelength excitation, allowing multiplexed assays for various biomedical applications. In vitro and in vivo ultrasound imaging indicated that nanobubbles had great contrast enhancement capability. In vivo fluorescence imaging showed the excellent ability to simultaneous multicolor imaging. The novel multicolor nanobubbles may have great potentials for a variety of applications in the study of life science and the clinical medicine.

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Publication details

The article was received on 08 Jul 2018, accepted on 25 Sep 2018 and first published on 08 Oct 2018

Article type: Paper
DOI: 10.1039/C8NR05488F
Citation: Nanoscale, 2018, Accepted Manuscript
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    Multicolor Nanobubbles for FRET/Ultrasound Dual-modal Contrast Imaging

    X. Zhang, R. Liu and Z. Dai, Nanoscale, 2018, Accepted Manuscript , DOI: 10.1039/C8NR05488F

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