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Issue 39, 2018
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A two-dimensional fingerprint nanoprobe based on black phosphorus for bio-SERS analysis and chemo-photothermal therapy

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Abstract

Flake-shaped nanohybrids based on black phosphorus (BP) have been developed as multifunctional theranostic nanoplatforms for drug delivery, phototherapy and bioimaging. In this work, we report a facile strategy for fabrication of black phosphorus-Au nanoparticle hybrids (BP-AuNPs), which reveal an extraordinary near-infrared (NIR) photothermal transduction efficiency and drug delivery capacity. The applications of the nanocomposites as therapeutic agents for high-performance chemo-photothermal tumor therapy are accomplished in vitro and in vivo. BP-AuNPs also exhibit wonderful surface-enhanced Raman scattering (SERS) activity under NIR laser excitation with a low Raman background, allowing BP-AuNPs to be used as a promising two-dimensional (2D) fingerprint nanoprobe for bio-SERS analysis. The cellular component identification and label-free live-cell bioimaging based on this type of 2D SERS substrate are generally investigated, which open up promising new perspectives in nanomedicine, including diagnosis, imaging and therapy.

Graphical abstract: A two-dimensional fingerprint nanoprobe based on black phosphorus for bio-SERS analysis and chemo-photothermal therapy

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Publication details

The article was received on 01 Jul 2018, accepted on 08 Sep 2018 and first published on 14 Sep 2018


Article type: Paper
DOI: 10.1039/C8NR05300F
Citation: Nanoscale, 2018,10, 18795-18804
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    A two-dimensional fingerprint nanoprobe based on black phosphorus for bio-SERS analysis and chemo-photothermal therapy

    Z. Liu, H. Chen, Y. Jia, W. Zhang, H. Zhao, W. Fan, W. Zhang, H. Zhong, Y. Ni and Z. Guo, Nanoscale, 2018, 10, 18795
    DOI: 10.1039/C8NR05300F

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