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Elemental and optical imaging evaluation of zwitterionic gold nanoclusters in glioblastoma mouse models

Abstract

We report in this study the in vivo biodistribution of ultra-small luminescent gold (Au) particles (∼1.5 nm core size; 17 kDa) so-called nanoclusters (NCs) stabilized by bidentate zwitterionic molecules in subcutaneous (s.c.) and orthotopic glioblastoma mice models. Particular investigations on renal clearance and tumor uptake were performed using highly sensitive advanced imaging techniques such as multi-elemental Laser-Induced Breakdown Spectroscopy (LIBS) imaging and In-line X-ray Synchrotron Phase Contrast Tomography (XSPCT). Results show a blood circulation time of 6.5±1.3 min accompanied with an efficient and fast renal clearance through the cortex of the kidney with a 66% drop between 1 h and 5 h. With a similar size range, these Au NCs are 5 times more fluorescent than the well-described NCs Au25GSH18 in the near-infrared (NIR) region and present a significantly stronger tumor uptake and retention illustrated by an in vivo s.c. tumor-to-skin ratio of 1.8 measured by non-invasive optical imaging and an ex vivo tumor-to-muscle of 6.1. This work highlights the pivotal role of the surface coating to design optimum Au NCs candidates for cancer treatment.

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Publication details

The article was received on 01 Jul 2018, accepted on 03 Sep 2018 and first published on 05 Sep 2018


Article type: Paper
DOI: 10.1039/C8NR05299A
Citation: Nanoscale, 2018, Accepted Manuscript
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    Elemental and optical imaging evaluation of zwitterionic gold nanoclusters in glioblastoma mouse models

    X. Le Guevel, M. Henry, V. Motto-Ros, E. Longo, M. I. Montañez, F. Pelascini, O. De la Rochefoucault, P. Zeitoun, J. Coll, V. Josserand and L. Sancey, Nanoscale, 2018, Accepted Manuscript , DOI: 10.1039/C8NR05299A

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