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Issue 43, 2018
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An acidic pH/reduction dual-stimuli responsive nanoprobe for enhanced CT imaging of tumours in vivo

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Abstract

Computed tomography (CT) is one of the most frequently used diagnostic imaging modalities in clinics. However, the fast clearance of CT contrast agents through the kidney and short circulation time severely restrict their in vivo applications. Herein, taking advantage of the biocompatible CBT condensation reaction, we rationally designed and synthesized a new smart acidic pH/glutathione (GSH) dual-stimuli responsive nanoprobe (1) which can intermolecularly undergo condensation and form a nanoparticle assembly (I-NPs) in the tumour microenvironment. In vivo CT imaging results indicated that probe 1 could be successfully applied for enhanced CT imaging of tumours in nude mice with a low dose of 21.79 mg I per kg body weight, which may offer a promising tool for precise tumor diagnosis.

Graphical abstract: An acidic pH/reduction dual-stimuli responsive nanoprobe for enhanced CT imaging of tumours in vivo

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Supplementary files

Article information


Submitted
22 Jun 2018
Accepted
21 Oct 2018
First published
22 Oct 2018

Nanoscale, 2018,10, 20126-20130
Article type
Communication

An acidic pH/reduction dual-stimuli responsive nanoprobe for enhanced CT imaging of tumours in vivo

A. Wang, L. Yin, L. He, H. Xia, F. Chen, M. Zhao, J. Ding and H. Shi, Nanoscale, 2018, 10, 20126
DOI: 10.1039/C8NR05061A

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