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Iron-oxide-based twin nanoplates with strong T2 relaxation shortening for contrast-enhanced magnetic resonance imaging

Abstract

Iron oxide nanomaterials have been intensively investigated over the past decades as magnetic resonance imaging (MRI) contrast agents (CAs) due to their favorable magnetism and excellent biocompatibility. However, commercial iron-oxide-nanoparticle-based CAs suffers from low T2 relaxivity, which significantly limits their applications in biomedical fields. Herein, we report a new type of iron oxide nanoplates (IOPs) with an interesting twinning plane, which are fabricated via seed growth. Compared with the conventional iron oxide (IO) spherical nanoparticles, iron oxide twin nanoplates (IOP-13) have larger effective radius, higher saturation magnetization, and greater anisotropy, resulting in their superior T2 relaxivity of 571.21 mM-1s-1 at 0.5 T, which is about six times higher than that of commercial IO nanoparticles. In vivo MR imaging demonstrated that IOP-13 could be used for liver imaging and liver tumor diagnosis with high sensitivity and accuracy, revealing the great potential of IOP-13 as next-generation CAs. This work provides a novel strategy of structure tuning to devise high-performance T2 contrast agents, which expands the applications of iron oxide nanoparticles in biology and materials.

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Publication details

The article was received on 20 Jun 2018, accepted on 29 Aug 2018 and first published on 30 Aug 2018


Article type: Paper
DOI: 10.1039/C8NR04995E
Citation: Nanoscale, 2018, Accepted Manuscript
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    Iron-oxide-based twin nanoplates with strong T2 relaxation shortening for contrast-enhanced magnetic resonance imaging

    R. Wei, T. Zhou, C. Sun, H. Lin, L. Yang, B. W. Ren, Z. Chen and J. Gao, Nanoscale, 2018, Accepted Manuscript , DOI: 10.1039/C8NR04995E

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