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Identifying macrophage enrichment in atherosclerotic plaques by targeting dual-modal US imaging/MRI based on biodegradable Fe-doped hollow silica nanospheres conjugated with anti-CD68 antibody

Abstract

Macrophage recruitment has emerged as the crucial force driving the initiation and progression of atherosclerotic lesions. Therefore, identification of macrophages in plaque is of vital importance for identifying vulnerable plaque, and noninvasive imaging methods are particularly desirable. Some researches have reported MRI can detect plaque macrophages though targeted nanoparticles, but it is still hard for US to detect macrophages in atherosclerotic plaque. In this study, anti-CD68 receptor-targeted Fe-doped hollow silica nanoparticles (CD68-Fe-HSNs) were fabricated as dual-modal US/MRI contrast agent for identifying macrophages of aorta ventralis atherosclerotic plaques in ApoE-/- mice, confirmed by immunofluorescence and bio-TEM. This system possesses biodegradable characteristics even though it is an inorganic mesoporous nanosystem, indicating its potential high biocompatibility for further in vivo research. We expect that this dual-modal US/MRI nanoparticles will play a role in assessing vulnerable plaque in future researches.

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Publication details

The article was received on 09 Jun 2018, accepted on 30 Sep 2018 and first published on 04 Oct 2018


Article type: Paper
DOI: 10.1039/C8NR04703K
Citation: Nanoscale, 2018, Accepted Manuscript
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    Identifying macrophage enrichment in atherosclerotic plaques by targeting dual-modal US imaging/MRI based on biodegradable Fe-doped hollow silica nanospheres conjugated with anti-CD68 antibody

    R. Ji, X. Li, C. Zhou, Q. Tian, C. Li, S. Xia, R. Wang, Y. Feng and W. Zhan, Nanoscale, 2018, Accepted Manuscript , DOI: 10.1039/C8NR04703K

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