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Membrane Destruction and Phospholipids Extraction by Two Dimensional MoS2 nanosheets

Abstract

The interaction of two-dimensional (2D) nanomaterials and bacterial membranes has attracted tremendous attention in the antibacterial applications. Various peculiarities of 2D nanomaterials may lead to multiple mechanisms of their interaction with membrane. Here, we investigated the interaction between molybdenum disulfide (MoS2) nanosheets and bacterial membrane by using both theoretical and experimental approaches. Molecular dynamic simulation presented that MoS2 nanosheet can disrupt the structure of lipid membrane by making dents on its surface and extracting phospholipid molecules to reduce the integrity of membrane. It attributes to the combination of the dispersion interaction of lipid tails with S atoms and the electrostatic interactions of lipid head groups with the Mo and S atoms in the lateral edges of MoS2 nanosheet. Scanning electron microscopy and transmission electron microscopy confirmed the dents and the destruction of cell membrane, which would lead to the loss of cytoplasm and the death of bacteria. It should be noted that the phenomenon that MoS2 induces dent is different from the direct insertion of graphene-based nanomaterials, which might be due to the thicker and stiffer structure of MoS2. Therefore, we believe that the molecular interaction of 2D nanomaterials with bacterial membranes should be highly correlated with their structural characteristics. This newly discovered mechanism of MoS2 nanomaterial to disrupt cell membrane may promote the application of transition metal dichalcogenide (TMD) nanomaterials in designing remarkable antibacterial materials in the near future.

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Publication details

The article was received on 24 May 2018, accepted on 05 Sep 2018 and first published on 06 Sep 2018


Article type: Paper
DOI: 10.1039/C8NR04207A
Citation: Nanoscale, 2018, Accepted Manuscript
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    Membrane Destruction and Phospholipids Extraction by Two Dimensional MoS2 nanosheets

    R. Wu, X. Ou, R. Tian, J. Zhang, H. Jin, M. Dong, J. Li and L. Liu, Nanoscale, 2018, Accepted Manuscript , DOI: 10.1039/C8NR04207A

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