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MoS2@polydopamine-Ag nanosheets with enhanced antibacterial activity for effective treatment of Staphylococcus aureus biofilms and wound infection

Abstract

Developing novel antibacterial agents to combat bacterial infection has been an everlasting task for scientists, due to the drug resistance evolved by bacteria during antibiotic treatment. In this work, we used polydopamine (PDA) to modify MoS2 nanosheets (MoS2 NSs) and then grew silver nanoparticles (AgNPs) on their surface to form MoS2@PDA-Ag nanosheets (MPA NSs) as multimodal antibacterial nanoagents to treat Staphylococcus aureus (S. aureus) biofilms and S. aureus infected wound. In vitro results show that after treatment by MPA NSs under near-infrared (NIR) laser irradiation can efficiently eradicate the established S. aureus biofilms with 99.99% of the bacteria inside biofilms killed, which shows significantly enhanced therapeutic efficacy compared with the MPA only group or NIR laser irradiation only group. Remarkably, MPA NSs were also successfully used to treat S. aureus infected wound in mice under near-infrared (NIR) laser irradiation. In vivo experiments demonstrated that about 99% of bacteria in wounds were killed and the healing of the infected wounds was also promoted. Overall, this work demonstrates that MPA NSs with enhanced antibacterial activity are promising nanoagents to treat S. aureus biofilms and S. aureus infected wound.

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Publication details

The article was received on 21 May 2018, accepted on 05 Aug 2018 and first published on 10 Aug 2018


Article type: Paper
DOI: 10.1039/C8NR04111C
Citation: Nanoscale, 2018, Accepted Manuscript
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    MoS2@polydopamine-Ag nanosheets with enhanced antibacterial activity for effective treatment of Staphylococcus aureus biofilms and wound infection

    L. Yuwen, Y. Sun, G. Tan, W. Xiu, Y. Zhang, L. Weng, Z. Teng and L. Wang, Nanoscale, 2018, Accepted Manuscript , DOI: 10.1039/C8NR04111C

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