Jump to main content
Jump to site search


Carbon dots with induced surface oxidation permits imaging at single-particle level for intracellular studies

Author affiliations

Abstract

For robust single particle optical detection, a high sensitivity in photoluminescence (PL) of Carbon Dots (CDs) must be achieved. PL sensitivity can be successfully correlated with their surface chemistry but requires high synthetic control without altering their basic surface properties. Here we describe conditions for the controlled synthesis of CDs that resulted in a PL sensitivity at the single-particle level. We report that a stoichiometric catalyst N-methyl morpholine-N-oxide (NMMO) can be used as a ‘sacrificial’ single additive to aid nanoscale surface oxidation. A 24 h NMMO-mediated oxidation increased coverage of oxidized nanoscale surface 3% to 20.9%. NMMO-oxidized CDs (CD-NMMOs) display superior particle brightness, as evidenced by the increase of light absorbance and an enhancement of quantum yield which is characterized by a series of physicochemical and biophysical experiments. We also demonstrate that CD-NMMOs is well suited for intracellular and single-particle imaging.

Graphical abstract: Carbon dots with induced surface oxidation permits imaging at single-particle level for intracellular studies

Back to tab navigation

Supplementary files

Publication details

The article was received on 19 May 2018, accepted on 15 Aug 2018 and first published on 16 Aug 2018


Article type: Paper
DOI: 10.1039/C8NR04065F
Citation: Nanoscale, 2018, Advance Article
  •   Request permissions

    Carbon dots with induced surface oxidation permits imaging at single-particle level for intracellular studies

    S. K. Misra, I. Srivastava, J. S. Khamo, V. V. Krishnamurthy, D. Sar, A. S. Schwartz-Duval, J. A. N. T. Soares, K. Zhang and D. Pan, Nanoscale, 2018, Advance Article , DOI: 10.1039/C8NR04065F

Search articles by author

Spotlight

Advertisements