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Graphene oxide–silver nanocomposites modulate biofilm formation and extracellular polymeric substance (EPS) production

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Abstract

Biofilms with positive and negative actions ubiquitously affect medical infections, environmental remediation and industrial processes. However, it remains challenging to control the growth of harmful biofilms as well as to exploit the use of beneficial biofilms. Here we investigated the effect of an antibacterial graphene oxide–silver nanoparticles (GO–AgNPs) composite on Pseudomonas aeruginosa biofilm formation. We found that GO–AgNPs prevented biofilm formation in a dose-dependent manner, with a threshold of 15 μg mL−1. Interestingly, the bacterial biomass significantly decreased, but extracellular polymeric substance (EPS) production remarkably increased in mature biofilms treated with GO–AgNPs of an appropriate concentration, suggesting that GO–AgNPs effectively modulate biofilm development and structure. Moreover, we established that GO–AgNPs caused bacterial death via both physical damage and oxidative stress, showing the synergic action of GO and AgNPs. These findings facilitate the use of graphene-based nanocomposites for greener antibiotic applications.

Graphical abstract: Graphene oxide–silver nanocomposites modulate biofilm formation and extracellular polymeric substance (EPS) production

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Publication details

The article was received on 19 May 2018, accepted on 17 Sep 2018 and first published on 25 Sep 2018


Article type: Paper
DOI: 10.1039/C8NR04064H
Citation: Nanoscale, 2018, Advance Article
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    Graphene oxide–silver nanocomposites modulate biofilm formation and extracellular polymeric substance (EPS) production

    S. Liu, S. Cao, J. Guo, L. Luo, Y. Zhou, C. Lin, J. Shi, C. Fan, M. Lv and L. Wang, Nanoscale, 2018, Advance Article , DOI: 10.1039/C8NR04064H

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