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Graphene oxide-silver nanocomposites modulate the biofilm formation and extracellular polymeric substances (EPS) production

Abstract

Biofilms with positive and negative actions ubiquitously affect medical infections, environmental remediation and industrial processes. However, it remains challenging to control the growth of harmful biofilms as well as to exploit the use of beneficial biofilms. Here we investigated the effect of antibacterial graphene oxide-silver nanoparticle (GO-AgNP) composite on Pseudomonas aeruginosa biofilm formation. We found that GO-AgNPs prevented biofilm formation in a dose-dependent manner, with a threshold of 15 μg/mL. Interestingly, the bacteria biomass significantly decreased but extracellular polymeric substances (EPS) production remarkably increased in mature biofilms treated with GO-AgNPs of appropriate concentration, suggesting that GO-AgNP effectively modulates biofilm development and structure. Moreover, we established that GO-AgNPs caused bacteria death via both physical damage and oxidative stress, showing the synergic action of GO and AgNPs. These findings facilitate the use of graphene-based nanocomposites for greener antibiotic applications.

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Publication details

The article was received on 19 May 2018, accepted on 17 Sep 2018 and first published on 25 Sep 2018


Article type: Paper
DOI: 10.1039/C8NR04064H
Citation: Nanoscale, 2018, Accepted Manuscript
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    Graphene oxide-silver nanocomposites modulate the biofilm formation and extracellular polymeric substances (EPS) production

    S. Liu, J. Guo, S. Cao, Y. Zhou, L. Luo, C. Lin, J. Shi, C. Fan, M. Lv and L. Wang, Nanoscale, 2018, Accepted Manuscript , DOI: 10.1039/C8NR04064H

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