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Issue 24, 2018
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An easy-to-fabricate clearable CuS-superstructure-based multifunctional theranostic platform for efficient imaging guided chemo-photothermal therapy

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Abstract

Despite drug delivery systems (DDSs) receiving ever-increasing attention, development of a simple, effective, sensitive and clearable drug delivery and multifunctional theranostic nanoplatform for cancer therapy is still highly desirable and remains a challenge. Herein, using a one-step solvothermal method, hollow acanthosphere-like CuS superstructures assembled from ∼10 nm nanoparticles (NPs) were successfully obtained and used as an efficient drug delivery and theranostic platform for photoacoustic (PA) and infrared (IR) thermal imaging-guided cancer combination therapy. The special hollow characteristic of CuS superstructures with mesoporous shells and large cavities grants them high drug loading capacity; they demonstrate near-infrared (NIR)/pH stimuli-sensitive drug release and pronounced synergetic effects of chemo-photothermal therapy both in vitro and in vivo. In particular, our as-fabricated hollow loose CuS superstructures, with easily breakable characteristic, are biodegradable and able to be cleared from the body when their therapy task is completed. This CuS-superstructure-based clearable drug delivery and “all-in-one” cancer theranostic platform might provide possibilities for improving therapeutic efficacy and minimizing adverse effects.

Graphical abstract: An easy-to-fabricate clearable CuS-superstructure-based multifunctional theranostic platform for efficient imaging guided chemo-photothermal therapy

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Publication details

The article was received on 21 Apr 2018, accepted on 19 May 2018 and first published on 22 May 2018


Article type: Paper
DOI: 10.1039/C8NR03271H
Citation: Nanoscale, 2018,10, 11430-11440

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    An easy-to-fabricate clearable CuS-superstructure-based multifunctional theranostic platform for efficient imaging guided chemo-photothermal therapy

    W. Zhang, J. Xiao, Q. Cao, W. Wang, X. Peng, G. Guan, Z. Cui, Y. Zhang, S. Wang, R. Zou, X. Wan, H. Qiu and J. Hu, Nanoscale, 2018, 10, 11430
    DOI: 10.1039/C8NR03271H

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