Jump to main content
Jump to site search

Issue 46, 2018
Previous Article Next Article

Mechanisms of (photo)toxicity of TiO2 nanomaterials (NM103, NM104, NM105): using high-throughput gene expression in Enchytraeus crypticus

Author affiliations

Abstract

Titanium dioxide (TiO2) based nanomaterials (NMs) are among the most produced NMs worldwide. When irradiated with light, particularly UV, TiO2 is photoactive, a property that is explored for several purposes. There are an increasing number of reports on the negative effects of photoactivated TiO2 on non-target organisms. We have here studied the effect of a suite of reference type TiO2 NMs (i.e. NM103, NM104, and NM105 and compared these to the bulk) with and without UV radiation to the oligochaete Enchytraeus crypticus. High-throughput gene expression was used to assess the molecular mechanisms, while also anchoring it to the known effects at the organism level (i.e., reproduction). Results showed that the photoactivity of TiO2 (UV exposed) played a major role in enhancing TiO2 toxicity, activating the transcription of oxidative stress, lysosome damage and apoptosis mechanisms. For non-UV activated TiO2, where toxicity at the organism level (reproduction) was lower, results showed potential for long-term effects (i.e., mutagenic and epigenetic). NM specific mechanisms were identified: NM103 affected transcription and translation, NM104_UV negatively affected the reproductive system/organs, and NM105_UV activated superoxide anion response. Results provided mechanistic information on UV-related phototoxicity of TiO2 materials and evidence for the potential long-term effects.

Graphical abstract: Mechanisms of (photo)toxicity of TiO2 nanomaterials (NM103, NM104, NM105): using high-throughput gene expression in Enchytraeus crypticus

Back to tab navigation

Supplementary files

Publication details

The article was received on 20 Apr 2018, accepted on 16 Oct 2018 and first published on 25 Oct 2018


Article type: Paper
DOI: 10.1039/C8NR03251C
Citation: Nanoscale, 2018,10, 21960-21970
  •   Request permissions

    Mechanisms of (photo)toxicity of TiO2 nanomaterials (NM103, NM104, NM105): using high-throughput gene expression in Enchytraeus crypticus

    S. I. L. Gomes, C. P. Roca, F. von der Kammer, J. J. Scott-Fordsmand and M. J. B. Amorim, Nanoscale, 2018, 10, 21960
    DOI: 10.1039/C8NR03251C

Search articles by author

Spotlight

Advertisements