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A functional preservation strategy produced highly photoluminescent emerald carbon dots for lysosome targeting and lysosomal pH imaging

Abstract

Lysosomes, which can be easily targeted by molecules with rich amino groups, play critical roles during the processes of endocytosis, autophagy, and phagocytosis, making it important to accurately characterize lysosomes including lysosomal pH in living cells so as to understand the physiological and pathological functions of lysosomes. Herein a new type of highly photoluminescent (PL) emerald carbon dots (CDs) were easily prepared through a functional preservation strategy (FPS) by simply mixing p-benzoquinone and ethanediamine at room temperature. The as-prepared CDs have rich amino groups preserved from ethanediamine owing to the FPS, hold excellent photostablility as compared to commercial LysoTracker probes, and thus actively target lysosome to sensitively respond the lysosomal pH in vitro owing to the abundant amino groups and good hydrophilicity, making it successfully monitored for the lysosomal pH dynamics during apoptosis in live cells.

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Publication details

The article was received on 19 Apr 2018, accepted on 09 Jul 2018 and first published on 11 Jul 2018


Article type: Paper
DOI: 10.1039/C8NR03212B
Citation: Nanoscale, 2018, Accepted Manuscript
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    A functional preservation strategy produced highly photoluminescent emerald carbon dots for lysosome targeting and lysosomal pH imaging

    Q. Q. Zhang, T. Yang, R. S. Li, H. Y. Zou, Y. F. Li, J. Guo, X. Liu and C. Z. Huang, Nanoscale, 2018, Accepted Manuscript , DOI: 10.1039/C8NR03212B

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